首页|Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases

Molecular events in the jaw vascular unit:A traditional review of the mechanisms involved in inflammatory jaw bone diseases

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Inflammatory jaw bone diseases are common in stomatology,including periodontitis,peri-implantitis,medication-related osteonecrosis of the jaw,radiation osteomyelitis of the jaw,age-related osteoporosis,and other specific infections.These diseases may lead to tooth loss and maxillofacial deformities,severely affecting patients'quality of life.Over the years,the reconstruction of jaw bone deficiency caused by inflammatory diseases has emerged as a medical and socioeconomic challenge.Therefore,exploring the pathogenesis of inflammatory diseases associated with jaw bones is crucial for improving prognosis and developing new targeted therapies.Accumulating evidence indicates that the integrated bone formation and dysfunction arise from complex interactions among a network of multiple cell types,including osteoblast-associated cells,immune cells,blood vessels,and lymphatic vessels.However,the role of these different cells in the inflammatory process and the'rules'with which they interact are still not fully understood.Although many investigations have focused on specific pathological processes and molecular events in inflammatory jaw diseases,few articles offer a perspective of integration.Here,we review the changes and mechanisms of various cell types in inflammatory jaw diseases,with the hope of providing insights to drive future research in this field.

inflammatory diseasesosteogenesis-related cellsimmune cellsblood vesselslymphatic vesselsjaw vascular unit

Ruyu Wang、Haoran Wang、Junyu Mu、Hua Yuan、Yongchu Pang、Yuli Wang、Yifei Du、Feng Han

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Department of Oral and Maxillofacial Surgery,the Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

Jiangsu Province Key Laboratory of Oral Diseases,Nanjing Medical University,Nanjing,Jiangsu 210029,China

Jiangsu Province Engineering Research Center of Stomatological Translational Medicine,Nanjing,Jiangsu 210029,China

International Joint Laboratory for Drug Target of Critical Illnesses,Key Laboratory of Cardiovascular and Cerebrovascular Medicine,School of Pharmacy,Nanjing Medical University,Nanjing,Jiangsu 211166,China

Department of Orthodontics,the Affiliated Stomatological Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

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Priority Academic Program Development of Jiangsu Higher Education InstitutionsJiangsu Province Capability Improvement Project through Science,Technology and Education-Jiangsu Provincial Research Hospital CuJiangsu Provincial Medical Innovation Center

PAPD-2018-87YJXYYJSDW4CXZX202227

2023

10.7555/JBR.36.20220266

生物医学研究杂志(英文版)
南京医科大学

生物医学研究杂志(英文版)

CSCD
影响因子：0.794
ISSN：1674-8301
年,卷(期)：2023.37(5)
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