首页|HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas

HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas

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Ionizing radiation is a popular and effective treatment option for glioblastoma(GBM).However,resistance to radiation therapy inevitably occurs during treatment.It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity.Here,we found that heat shock protein 90 beta family member 1(HSP90B1)was significantly upregulated in radioresistant GBM cell lines.More importantly,HSP90B1 promoted the localization of glucose transporter type 1,a key rate-limiting factor of glycolysis,on the plasma membrane,which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells.These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients,a potential new approach to the treatment of glioblastoma.

HSP90B1glycolysisGLUT1glioblastomaradiotherapy

Yanhui Li、Yuqian Ge、Mengjie Zhao、Fangshu Ding、Xiuxing Wang、Zhumei Shi、Xin Ge、Xiefeng Wang、Xu Qian

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Department of Nutrition and Food Hygiene,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China

Institute for Brain Tumors,Jiangsu Key Lab of Cancer Biomarkers,Prevention and Treatment,Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China

Department of Neuro-Psychiatric Institute,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

National Health Commission Key Laboratory of Antibody Technologies,Nanjing Medical University,Nanjing,Jiangsu 211166,China

Department of Cell Biology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China

Department of Neurosurgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of China

8207276582172667

2023

10.7555/JBR.37.20220234

生物医学研究杂志(英文版)
南京医科大学

生物医学研究杂志(英文版)

CSCD
影响因子：0.794
ISSN：1674-8301
年,卷(期)：2023.37(5)
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