首页|hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice

hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice

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Anti-cancer therapy often causes premature ovarian insufficiency and infertility as the ovarian follicle reserve is extremely sensitive to chemotherapy drugs,such as cisplatin.Various fertility preservation methods have been explored for women,especially prepubertal girls undergoing radiotherapy and chemotherapy due to cancer.In recent years,mesenchymal stem cell-derived exosomes(MSC-exos)have been reported to play an important role in tissue repair and the treatment of various diseases.In the current study,we observed that human umbilical cord-derived MSC-exos(hucMSC-exos)after short-term culture improved follicular survival and development while receiving cisplatin treatment.Moreover,intravenous injection of hucMSC-exos improved ovarian function and ameliorated inflammatory environment within the ovary.The underlying mechanism of hucMSC-exos on fertility preservation was associated with the down-regulation of p53-related apoptosis and their anti-inflammatory function.Based on these findings,we propose that hucMSC-exos may be a potential approach to improve fertility in women diagnosed with cancer.

ovarian functionovarian reservecisplatinexosomesapoptosis

Yue Xiao、Yue Peng、Chi Zhang、Wei Liu、Kehan Wang、Jing Li

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State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 210029,China

National Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaNational Natural Science Foundation of China

2018YFC10037032018YFC100420331871513

2023

10.7555/JBR.36.20220166

生物医学研究杂志(英文版)
南京医科大学

生物医学研究杂志(英文版)

CSCD
影响因子：0.794
ISSN：1674-8301
年,卷(期)：2023.37(5)
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