OBJECTIVE To explore the clinical efficacy of Wandai Decoction in the treatment of vulvovaginal candidiasis(VVC)with spleen deficiency-dampness abundance and its effect on DNA damage.METHODS 70 VVC patients with spleen deficiency-dampness abundance who met the inclusion criteria were randomly divided into Wandai Decoction and fluconazole groups,35 cases each.The fluconazole group took 150 mg fluconazole orally once;the Wandai Decoction group took Wandai Decoction orally for 14 d.After treatment,changes in TCM syndrome scores of the two groups of patients were compared;the clinical cure(test of cure,TOC)rate and clinical improvement(CI)rate of the two groups of patients were evaluated;8-hydroxydeoxyguanosine(8-OHDG)in the vaginal lavage fluid was detected by colorimetry to assess DNA damage;clinical complete remission(follow up,FU),mycological negative conversion and recurrence rate were evaluated 3 months after treatment.RESULTS After treatment,the TCM syndrome scores of the two groups of patients were improved to varying degrees(P<0.05,P<0.01);the Wandai Decoction group was superior to the fluconazole group(P<0.05,P<0.01);there was no significant difference in TOC,CI,mycology negative conversion between the Wandai Decoction group and the fluconazole group(P>0.05);however,the FU and recurrence rate of the Wandai Decoction group were significantly better than those of the fluconazole group(P<0.05,P<0.01).After treatment,the expression of 8-OHDG in the vaginal lavage fluid of the fluconazole group increased significantly(P<0.001),while there was no significant change in the Wandai Decoction group,which was significantly lower than that of the fluconazole group(P<0.001).CONCLUSION The overall clinical efficacy of Wandai Decoction is equivalent to that of fluconazole,but it is better than fluconazole in improving TCM syndromes and pre-venting recurrence,with the advantage of not aggravating DNA damage in vaginal cells.
维普
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