CENPF促进肾透明细胞癌的增殖、迁移和侵袭
CENPF Promotes the Proliferation,Migration,and Invasion of Renal Clear Cell Carcinoma
廖文峰 1王坤 1张振庭 1陈旭升 1姚欣1
作者信息
- 1. 天津医科大学肿瘤医院泌尿肿瘤科,国家恶性肿瘤临床医学研究中心,天津恶性肿瘤临床医学研究中心,天津"肿瘤防治"重点实验室,天津300060
- 折叠
摘要
肾透明细胞癌(RCCC)是最常见的肾癌类型,以其高转移性、侵袭性和形态多样性而闻名.为了早期诊断和精确治疗,迫切需要更多的生物标志物和治疗靶点.着丝粒蛋白F(CENPF)是一种微管结合蛋白,也是细胞周期相关的核抗原.最近的研究表明,CENPF影响多种细胞过程,如有丝分裂和囊泡运输.CENPF对肿瘤进展和转移的广泛影响也已被揭示,然而,CENPF对肾癌,特别是RCCC的影响尚不清楚.本研究发现,CENPF在人RCCC组织中有明显的高表达,且其表达与RCCC患者的预后、肿瘤大小和肿瘤分期等临床病理特征相关.同时发现,CENPF能促进体外RCCC细胞的增殖、迁移和侵袭,并促进小鼠肿瘤的生长.因此,证实了 CENPF参与RCCC的进展,并认为CENPF可以作为RCCC治疗的有希望的靶点.
Abstract
Renal clear cell carcinoma(RCCC)is the most common type of renal cancer,which is known for its high metastasis,aggressive behavior,and morphologic diversity.For early diagnosis and pre-cise treatment,more biomarkers and therapeutic targets are badly needed.Centromere protein F(CENPF)is a microtubule-binding protein as well as a cell cycle-associated nuclear antigen.Recent studies demon-strated that CENPF affected multiple cellular processes,such as mitosis and vesicular transport.The wide effects of CENPF on the progression and metastasis of tumors have also been revealed,however,the ef-fects of CENPF on renal cancer,especially RCCC,remain unknown.Herein,the obvious high expression of CENPF in human RCCC tissues was found,and the expression of CENPF was correlated with the prognosis and clinical pathological features including tumor size and tumor stage of RCCC patients.CENPF promoted the proliferation,migration,and invasion of RCCC cells in vitro,and contributed to tumor growth and metastasis in mice.Therefore,the involvement of CENPF in RCCC progression was confirmed and CENPF could act as a promising therapeutic target for RCCC treatment.
关键词
肾透明细胞癌/着丝粒蛋白F(CENPF)/增殖/迁移/侵袭/预后Key words
renal clear cell carcinoma(RCCC)/centromere protein F(CENPF)/proliferation/migration/invasion/prognosis引用本文复制引用
基金项目
Tumor Surgery Precision Treatment Technology Construction Project of Tianjin Medical University Cancer Hospital(ZLWKJZZL08)
出版年
2023
NETL
NSTL
维普
万方数据