Mechanism Exploration of Xiaoxianxiong Decoction in the Treatment of SARS-CoV-2
As a traditional prescription,Xiaoxianxiong Decoction and its verified prescriptions are used in the clinical treatment for COVID19(Corona Virus Disease 2019).Though it has broad practical basis,the mechanism of its anti-inflammatory active ingredients is still unobscured.Along with the development of genomics and proteomics,massive amounts of bioinformatics data can be used to analyze the mechanism of drug-disease in the protein,molecular,and genetic levels.Active ingredients of Xiaoxianxiong Decoction were screened through network pharmacology,its regulatory effect on immune cells was explored,and its possibility of treating COVID-19 at the molecular level was further verified.The results showed that main activated components of Xiaoxianxiong Decoction to treat COVID-19 were quercetin,baicalein,β-sitosterol,diosmetin.Those active ingredients could up-regulate level of CD4+T cells and the ratio of CD4+/CD8+to regulate excessiveimmune response.The study also suggested that Baicalein could inhibit the replication function of 3CLpro by binding to the critical site of 3CLpro,an essential protein of the new coronavirus,and achieving antiviral effect.Quercetin could reduce lung inflammation by improving the differentiation of regulatory T cells.Diosmetin could enhance human innate immunity by regulating the differentiation of macrophages and increasing the proportion of NK cells,thus playing a role in the treatment of COVID-19.
COVID-19Xiaoxianxiong DecoctionCD4+ T cellsNK cellsmacrophages3C-like protease
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