The global situation of the coronavirus disease 2019(COVID-19)infection remains concerning.As the viruses continue to evolve,the risk of reinfection has markedly increased.COVID-19 vaccination history,previous infection history,antibody titers,age and immune escape can all affect the occurrence of reinfection.Scientific rehabilitation training can help to alleviate post-acute COVID-19 sequalae,and vaccination remains a crucial measure of infection prevention.In the paper,we discussed the current epidemic situation of COVID-19,epidemiology of reinfection and its'related factors,and strategies to provide reference for epidemic prevention and control.