一氧化氮在新型冠状病毒感染中的应用
Application of nitric oxide in corona virus disease 2019
王亚婷 1贺春伟 1付紫玉 1王慧 1马德东1
作者信息
- 1. 山东大学齐鲁医院呼吸与危重症医学科,山东济南 250012
- 折叠
摘要
新型冠状病毒感染(coronavirus disease 2019,COVID-19)的发生造成了世界范围的医疗危机和卫生资源紧张.一氧化氮(nitric oxide,NO)在2003年严重急性呼吸综合征(severe acute respiratory syndrome,SARS)期间被证明可以改善氧合,降低肺动脉压力,减少无创通气的需求.SARS冠状病毒(SARS coronavirus,SARS-CoV)与SARS-CoV-2遗传结构和病理特征具有重叠性,并且NO具有抗病毒、舒张血管、抗凝、抗炎作用.本文拟对NO在COVID-19中的应用展开综述,以期为后续COVID-19患者的治疗提供思路.
Abstract
The outbreak of coronavirus disease 2019(COVID-19)has caused a worldwide medical crisis and strained health resources.Nitric oxide(NO)is shown to improve oxygenation,reduce pulmonary artery pressure,and reduce the need for noninvasive ventilation during severe acute respiratory syndrome(SARS)in 2003.SARS coronavirus(SARS-CoV)and SARS-CoV-2 have overlapping genetic structure and pathological characteristics,and NO has antiviral,vasodilator,anticoagulant and anti-inflammatory effects.This article reviewed the application of NO in COVID-19 patients,to provide the treatment strategy for new COVID-19 patients.
关键词
一氧化氮/新型冠状病毒感染/急性呼吸综合征冠状病毒-2/血管舒张/抗病毒Key words
Nitric oxide/Coronavirus disease 2019/Severe acute respiratory syndrome coronavirus 2/Vasodilation/Antivirus引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据