Effect of Shenfu injection on immune function in elderly patients with sepsis
Objective To explore the effect of Shenfu injection on immune function in elderly patients with sepsis.Methods This study was a retrospective analysis.The elderly patients(n=126)with sepsis admitted to 4 hospitals including Shanghai Ruijin Hospital from January 2019 to December 2020 were divided into two groups according to whether Shenfu injection was used(61 cases in Shenfu group,65 cases in control group).Basic data,comorbidities,relevant test results(including inflammatory factors,humoral immune indicators,cellular immune indicators,etc.),disease severity score,mortality rate,etc.,were collected for statistical analysis.Results After seven days of Shenfu injection treatment,the indexes including the mean artery pressure(MAP),lactate(Lac),C-reactive protein(CRP),procalcitonin(PCT),prothrombin time(PT),activated partial thromboplastin time(APTT),interleukin-6(IL-6),IL-10,tumor necrosis factor-α(TNF-α),CD3 count,CD4 count,CD8 count,IgG,IgA and IgM of patients in 2 groups were significantly improved(all P<0.05).Compared with the control group,MAP(P=0.034),and the absolute count of CD3(P=0.002)and CD4(P=0.002)were significantly increased in the Shenfu treated group.Conclusions Shenfu injection combined with standard bundled regimen can improve the immune function and reduce inflammation in elderly patients with sepsis.
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