An exploratory study of periodontal therapy to improve non-alcoholic fatty liver disease
Objective To study the effect of Porphyromonas gingivalis(P.g)on non-alcoholic fatty liver disease(NAFLD)and the ameliorative effect of periodontal treatment on NAFLD.Methods Mice fed a high-fat diet for 4 weeks were randomly divided into two groups,and there were 8 mice in each group.Group A was blank control,and Group B was given suture ligation+smeared P.g.They were sacrificed after 4 weeks of intervention,and the changes in liver,inflammatory factors were tested.Eight NAFLD patients with periodontal disease were randomly divided into the subgingival scaling group and the control group(4 in each group),and the subgingival scaling group received the basic periodontal treatment.Changes in periodontal status,liver,and blood biochemistry before and after the intervention were tested in the 2 group patients.Results Compared with the control mouse group,the ligation and smear mouse group had increased liver weight,formation of lipid deposits,serum lipid,aspartate transaminase and ferritin levels,and the expression of serum inflammatory mediators was increased.Compared with the patients in the tooth brushing group,the subgingival scraping patient group showed a significantly decreased indexes such as P.g-IgG antibody titer,probing depth,as well as a downward trend in liver fat content,but the differences were not statistically significant(P>0.05).Conclusions P.g infection can accelerate the progression of NAFLD in mice with high-fat diet,and the periodontal treatment in patients showed a mitigating effect on periodontal infection-associated NAFLD.
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