Hyperthyroidism is most common in Graves disease(GD),and traditional antithyroid medicine are often difficult to achieve satisfactory efficacy,and high recurrence rate and long course of treatment are the most prominent problems.Huangyaozi(Dioscorea bublifera L.),a traditional Chinese medicine,has the effect of"Xiao Ying"and has been widely used in the treatment of GD in recent years,but long-term use may cause liver and kidney damage.Therefore,more research on the efficacy and safety of Huangyaozi need to be done in the treatment of GD.