Study on the correlation between serum MG53 level and coronary artery calcification
Objective To study the correlation between serum MG53 level and coronary artery calcification(CAC),and the correlation between serum MG53 level and the prognosis of patients with CAC.Methods A total of 195 patients admitted to the Department of Cardiovascular Medicine of Ruijin Hospital,Shanghai Jiao Tong University School of Medicine from 2016 to 2018 due to chest distress and other discomforts were selected.CAC was confirmed by coronary CT angiography(CTA)in all patients.Agatston integral was used to calculate CAC score,and serum MG53 level was detected by enzyme-linked immunosorbent assay.Patients were followed up for 5 years,and the endpoint events were recorded.Patients were grouped according to CAC score and serum MG53 level.Logistic regression was used to analyze the correlation between serum MG53 level and CAC level.Kaplan-Meier curve and COX proportional risk model were used to analyze the effect of serum MG53 level on the prognosis of CAC patients.The R software(4.2.2 version)was used to calculate the best cut-off value of serum MG53 level for predicting end-point events.Results Compared with the low-risk group,the serum MG53 level in the high-risk group was significantly lower[57.717(28.548,139.965)pg/mL vs 33.553(13.509,56.952)pg/mL,P<0.001].Serum MG53 level was independently associated with the severity of CAC(OR=0.984,95%CI:0.971-0.994,P<0.007).The risk of cardiovascular events was significantly increased in patients with low MG53 levels(OR=0.282,95%CI:0.160-0.498,P<0.001).The cutoff value of MG53 was calculated as 18.36 pg/mL.Conclusions Serum MG53 level may be related to the degree of CAC and the prognosis of patients,suggesting that serum MG53 level may be a biomarker for predicting CAC and the prognosis of patients.
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