Invasive pulmonary aspergillosis secondary to immunosuppressive therapy in nephrotic syndrome:a case report
A 61-year-old male with a one-year history of membranous nephropathy was placed on combined therapy of glucocorticoids and rituximab.On the 12th day of treatment,the patient developed high fever,accompanied by mild cough and night sweats.Chest CT revealed multiple nodules and patchy opacities in both lungs.Bronchoalveolar lavage fluid(BALF)analysis using next-generation sequencing(NGS)identifed Aspergillus infection,and two consecutive β-D-glucan tests were positive.The clinical diagnosis of invasive pulmonary aspergillosis(IPA)was established.The patient received intravenous voriconazole for six months.Follow-up chest CT showed significant absorption of pulmonary lesions.The treatment regimen led to recovery of the patient and achieved partial remission of nephrotic.
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