凝血因子ⅩⅢ与静脉血栓栓塞症研究进展
Research progress of coagulation factor ⅩⅢ and venous thromboembolism
谢学猛 1胡玲2
作者信息
- 1. 济宁医学院附属医院重症医学科,山东 济宁 272007
- 2. 济宁医学院临床医学院,山东 济宁 272067
- 折叠
摘要
静脉血栓栓塞症(venous thromboembolism,VTE)是世界范围内第三大常见心血管疾病,其发病率仍然呈上升趋势.凝血因子ⅩⅢ(factor ⅩⅢ,F ⅩⅢ)又称纤维蛋白稳定因子,参与凝血级联反应的多个环节.近来研究发现F ⅩⅢ是决定静脉血栓体积、结构和稳定性的关键因子,可能在深静脉血栓的形成、脱落或溶解过程中扮演重要角色.本文就此展开综述,以期为VTE的预防、诊断和治疗提供新思路.
Abstract
Venous thromboembolism(VTE)is the third most common cardiovascular disease worldwide,and its incidence continues to rise.Coagulation factor ⅩⅢ(F ⅩⅢ,factor ⅩⅢ),also known as fibrin stabilization factor,is involved in multiple stages of the clotting cascade.Recent studies have found that F ⅩⅢ is a key factor in determining the volume,structure and stability of venous thrombosis,and may play an important role in the formation,shedding or dissolution of deep venous thrombosis.This paper reviews the research progress of F ⅩⅢ and VTE,in order to provide new ideas for the prevention,diagnosis and treatment of VTE.
关键词
静脉血栓栓塞症/深静脉血栓形成/肺栓塞/凝血因子ⅩⅢKey words
Venous thromboembolism/Deep vein thrombosis/Pulmonary embolism/Coagulation factorⅩⅢ引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据