Objective:To investigate the association of A disintegrin and metalloproteinase with thrombospondin motifs 7(ADAMTS7)rs62011052 and rs62012628 locus polymorphisms with essential hypertension.Methods:211 cases of essential hypertension were selected,and 208 cases of people with normal blood pressure in the same period of physical examination were selected as the control group,and the genotype was determined by Sanger method sequencing;SPSS25.0 software was used to compare the correlation between clinical data,gene polymorphism and essential hypertension between groups.Resu1ts:(1)Compared to the control group,the hypertensive group had higher BMI,pulse pressure difference,systolic blood pressure,diastolic blood pressure,triglycerides,total bile acids,uric acid,faster resting heart rate and lower HDL(P＜0.05);the remaining clinical information was not statistically significant(P＞0.05).(2)The genotype distribution of the rs62011052 and rs62012628 loci between the two groups was consistent with Hardy-Weinberg equilibrium(P＞0.05);the differences in genotype frequency and allele frequency at the rs62011052 and rs62012628 loci between the two groups were not statistically significant(P＞0.05),and af-ter stratifying the two groups by sex analysis,the differences remained statistically insignificant(P＞0.05).(3)After ad-justing for possible confounding,no significant association was seen between people carrying different genotypes at the rs62011052 and rs62012628 loci and the risk of developing hypertension under different genetic models(P＞0.05).(4)The difference in blood pressure values between genotypes under the different genetic models was not statistically significant at rs62011052(P＞0.05);the difference in diastolic blood pressure between genotypes under the co-dominant model was statistically significant at rs62012628(P＜0.05),and a subsequent two-by-two comparison revealed that the diastolic blood pressure of genotype CT was lower than that of genotype CC in the co-dominant model(P＜0.05),the CT+TT genotype had lower blood pressure values than the CC genotype in the dominant model(P＜0.05),and the rest of the differences between genotypes in the different genetic models were not statistically significant(P＞0.05).Conc1usion:The T allele at locus rs62012628 of the ADAMTS7 gene is associated with lower levels of blood pressure values.
维普
万方数据