Objective:To explore the associations of homocysteine(Hcy)metabolism-related genes MTHFR polymorphisms and folate with H-type hypertension in Kazakhs.These results provide support and a theoretical basis for the pathogenesis research of H-type hypertension.Methods:A case-control study,using data from the"Xinjiang Kazakhs H-type ypertension Cross-sectional study"was conducted.A total of 400 subjects were randomly selected,which included 300 cases and 100 controls.Among them,the case groups included 100 patients with H-type hypertension,100 patients with uncomplicated hypertension,and 100 patients with Hyperhomocysteinemia(HHcy).Genetic testing of MTHFR(rs1801133,rs1801131)was performed using Sanger sequencing.Folate was detected by electrochemiluminescence assay.Hardy-Weinberg equilibrium was tested by Pearson's chi-square(X 2)test.We applied unconditional logistic regression to analysis was carried out to analyze the association of MTHFR gene and folate with H-type hypertension.Results:Compared with the healthy control group,the high level of folate was a protective factor for H-type hypertension(OR=0.33,95％CI:0.15-0.72),while rs1801133-(CT+TT)was a risk factor(OR=6.37,95％CI:2.97-13.68).Meanwhile,the high level of folate was a protective factor for HHcy(OR=0.45,95％CI:0.23-0.86),while rs1801133-(CT+TT)was a risk factor(OR=2.92,95％CI:1.52-5.62).Conclusions:The T allele and CT+TT genotypes of MTHFR rs1801133 were risk factors for H-type hypertension in Kazakhs,while the high level of folate was a protective factor for H-type hypertension.
维普
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