Objective:To discuss the relative localization methods of preoperative computed tomography(CT)-guided and their clinical value to assist clinical doctor remove the high-risk pulmonary nodules during the video-assisted therapeutic surgery(VATS).Methods:Clinical data of 143 lung nodules(LNs)in 125 patients located underwent CT-guide before video-assisted therapeutic surgery(VATS)were analyzed retrospectively from January 2020 and July 2022 at the cardiothoracic surgery department of First Affiliated Hospital of Shihezi University,including 59 cases(60 LNs)in methylene blue(MB)group,42 cases(51 LNs)in the coil group and 24 cases(32 LNs)in coil combined MB group.We compared the technical success of localization and wedge resection between three groups.Results:There were no significant differences in technical success rates of localization and wedge resection between the three groups(P=0.634 and 0.719).MB group show a significant difference to the coil group and coil combined MB group(P=0.036 and 0.013,P=0.003 and 0.003)in complication incidence and the range of wedge resection,respectively.But there is no significant difference between coil group and coil combined MB group(P=0.592 and P=0.286).Conclusion:The three methods of preoperative CT-guided with methylene-blue,coil or coil combined methylene-blue localization for lung nodules show a similar effectiveness feasibility.Relative to MB localization,coil and coil combined MB localization show a smaller range of wedge resection.Relative to the diffusion property of MB localization,the stable coil localization might be compatible with a longer delay for the schedule of VATS.The combination of coil and MB localization cannot significantly improve the accuracy of coil localization,but rather has a certain impact on pathological results.It is not recommended to use both in combination.