Prognostic Effect of Cytoplasmic LncRNAs on Hepatocarcinoma in CeRNA Network
Abnormal expression of long non-coding RNAs(lncRNAs)plays a crucial role in the occurrence and development of liver cancer(HCC).Moreover,the specific function of lncRNAs is closely related to their intracellular localizations.LncRNAs are widely located in cytoplasm and nucleus,but competitive endogenous RNAs(ceRNAs)mainly act in cytoplasm,lncRNAs located in cytoplasm are selected.The expression profiles of lncRNAs,microRNAs(miRNAs)and messenger RNAs(mRNAs)in 374 HCC tissues and 50 normal tissues are obtained from the Cancer Genome Atlas(TCGA),and the differentially expressed genes are identified.A ceRNA network associated with HCC is constructed,and then a prognosis model based on five lncRNA genes is constructed by establishing LASSO Cox model and multivariate Cox regression analysis.HCC samples are divided into high and low risk groups,and KM survival analysis shows that patients in the high risk group have a poor prognosis.Through univariate and multifactorial analysis,it is found that this model may be an independent factor in predicting liver cancer patients.The conclusions suggest that some potential prognostic cytoplasmic lncRNAs involved in HCC progression have been identified.
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