结肠癌是世界上第三大诊断癌症，也是癌症相关死亡的第二大原因。随着生物技术的不断发展，人们发现长链非编码RNA(long non-coding RNA，lncRNA)和铁死亡在结肠癌的预后中起着重要的作用。因此，研究铁死亡与lncRNA之间的关系将对改善结肠癌患者的预后生存有所帮助。本文筛选了结肠癌组织和正常组织中差异表达的铁死亡相关基因，并进行GO(Gene ontology)和 KEGG(Kyoto encyclopedia of genes and genomes)富集分析。筛选出与结肠癌预后相关的铁死亡相关lncRNA，通过LASSO分析构建了基于5个lncRNA基因的预后模型。将结肠癌样本分为高、低风险组，对该模型进行KM(Kaplan-meier)生存分析和ROC分析，KM分析结果显示高风险组的预后较差;ROC结果表明，该模型能较好地预测结肠癌的生存。本文构建的基于铁死亡相关lncRNA的预后模型可以准确预测结肠癌患者的预后状态，这为结肠癌的预后和治疗提供了一定的理论依据。
Construction and Analysis of Prognosis Model of Colon Cancer Based on Ferroptosis-Related LncRNAs
Colon cancer is the third most diagnosed cancer in the world and the second leading cause of cancer-related death.With the continuous development of biotechnology,it has been found that long non-coding RNAs(lncRNAs)and ferroptosis play an important role in the prognosis of colon cancer.Therefore,studying the relationship between ferroptosis and lncRNAs will be helpful to improve the prognosis of colon cancer patients.In this article,the differentially expressed genes related to ferroptosis in colon cancer tissues and normal tissues were screened and analyzed for GO(Gene ontology)and KEGG(Kyoto encyclopedia of genes and genomes)enrichment.Ferroptosis-re-lated lncRNAs were screened out,and a prognostic model based on five lncRNA genes was construc-ted by LASSO analysis.Colon cancer samples were divided into high and low risk groups.Kaplan-meier(KM)survival analysis and ROC analysis were performed on the model,and the results of KM analysis showed that the high risk group had poor prognosis.ROC results showed that the model was a good predictor of colon cancer survival.The prognosis model based on ferroptosis-related ln-cRNA established can accurately predict the prognosis of colon cancer patients,and provide a certain theoretical basis for the prognosis and treatment of colon cancer.
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