Study on the Mechanism of FAM83A Gene and Its Regulators on the Development and Progression of Lung Adenocarcinoma
The FAM83 gene family plays an oncogenic role in a variety of cancers,and we used FAM83A as a representative to explore its oncogenic mechanism.FAM83A is an oncogene in many cancers,especially in LUAD(lung adenocarcinoma).In this paper,we downloaded 594 LUAD data from TCGA database to analyze the oncogenic principle of FAM83A in LUAD.The results showed that the high expression of FAM83A has a significant effect on the development of lung adenocarci-noma and the progression from stage T1 to stage T2.By analyzing RNAs and DNA methylation lev-el associated with FAM83A expression,we found four target lncRNAs and 18 methylation sites that were significantly associated with FAM83A expression.Tissue enrichment and functional enrich-ment analysis of FAM83A and its co-expressed genes showed that FAM83A was mainly enriched in lung,breast and colon tissues as well as immune cells and non-small cell lung cancer related path-ways.These results indicated that FAM83A may be a potential biomarker in the prevention and treatment of lung adenocarcinoma.
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