Protein phosphorylation is one of the most important reversible post -translational modifications (PTMs) , and the theoretical recognition of the phosphorylation site is an important task in computational biology researches. The conservative characteristic of residue fragments around the phosphorylation site has some relation with protein kinase. In this paper,CK2,PKA and PKC phosphorylation sites,which have relatively more enzyme annotation data,are chosen as the object of study,and the sequence component characteristic,the characteristic of residue position specificity,as well as the characteristic of residue pairnon-close neighbor relevancy,are taken as parameters. And,Jensen-Shannon Divergence with Quadratic Discriminant analysis(JSDQD)is used as the method for predicting the phos-jshorylation sites. The 7 -fold cross-validation test accuracies of CK2,PKA and PKC are,respectively, 90%, 90% and 86%,which are higher than those obtained by other prediction models used curnent-ly.
protein phosphorylation siteJensen -Shannon divergencequadratic discriminant a-nalysis
NETL
NSTL
万方数据
维普
