Recent Progress in the Roles of Integrin in Regulating Bone Health in Livestock and Poultry via PI3K/Akt Signaling Pathway
Bone is the hard connective tissue in vertebrates,which has the functions of constituting the basic scaffolding of the body,protecting organs,supporting body weight and maintaining locomotion.Skeletal development is mainly accomplished through intramembranous osteogenesis and endochondral ossification,and is a process in which a complex regulatory network of multiple regulatory factors works together to maintain bone health in livestock and poultry.Integrin is a trans-membrane receptor on the cell membrane that mediates cell-matrix interactions.It not only has the role of causing cell adhesion,but is also capable of triggering corresponding responses in the body through bidirectional transmission of intracellular and extracellular signals.Integrin regulates multiple signaling pathways,including phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway,and plays an important role in maintaining bone health in livestock and poultry.PI3K/Akt signaling pathway is mediated by enzyme-linked receptors and is capable of regulating cellular life activities.It can regulate cartilage metabolism homeostasis through inflammation,autophagy and apoptosis,which is of great importance for maintaining bone health.Based on the research progress in the relationships among bone metabolism,integrin and PI3K/Akt signaling pathway in livestock and poultry both domestically and internationally,this article reviews the effects of integrin and PI3K/Akt signaling pathway on bone metabolism,and the impacts of integrin on bone metabolism via PI3K/Akt signaling pathway,in hoping to provide theoretical bases for exploring the key role of integrin in regulating bone health in livestock and poultry via PI3K/Akt signaling pathway.
integrinPI3K/Akt signaling pathwaybone metabolismbone health
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维普
