Meta-analysis of Clinical Outcomes of Traditional Chinese Medicines in Treating Chronic Heart Failure
Objective:To systematically evaluate the impact of Chinese patent medicine related treatment regimens compared with conven-tional western medicine or placebo treatment on the overall clinical efficacy and related outcome indicators in patients with chronic heart fail-ure(CHF).Methods:8 databases were searched for randomized controlled trials of Chinese patent medicine related treatment options com-pared with conventional western medicine or placebo in the treatment of CHF patients from 2014 to 2024,and Meta-analysis was performed using Stata16.0 software.Results:Finally,35 articles were included.The results showed that compared with conventional western medicine or placebo treatment,treatment options related to proprietary Chinese medicines can effectively improve the overall clinical efficacy of CHF pa-tients.(RR=1.22;95％CI=1.18,1.26;P＜0.0001)、LVEF(SMD=1.03;95％C]=0.82,1.25;P＜0.0001)、LVESD(SMD=-0.70;95％CI=-0.86,-0.53;P＜0.0001)、LVEDD(SMD=-0.77;95％CI=-0.97,-0.58;P＜0.0001),NT-proBNP(SMD=-0.57;95％CI=-0.69,-0.45;P＜0.0001)and the in-cidence of adverse reactions(RR=0.57;95％CI=0.35,0.94;P=0.028＜0.05).Conclusion:Chinese patent medicine related treatment regi-mens can effectively improve the overall clinical efficacy,cardiac function indicators and the incidence of adverse reactions in patients with CHF.
万方数据
维普
