首页|Demands and technical developments of clinical flow cytometry with emphasis in quantitative, spectral, and imaging capabilities

Demands and technical developments of clinical flow cytometry with emphasis in quantitative, spectral, and imaging capabilities

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As the gold-standard method for single-cell analysis, flow cytometry enables high-throughput and multiple-parameter characterization of individual biological cells. This review highlights the demands for clinical flow cytometry in laboratory hematology (e.g., diagnoses of minimal residual disease and various types of leukemia), summarizes state-of-the-art clinical flow cytometers (e.g., FACSLyricTM by Becton Dickinson, DxFLEX by Beckman Coulter), then considers innovative technical improvements in flow cytometry (including quantitative, spec-tral, and imaging approaches) to address the limitations of clinical flow cytometry in hematology diagnosis. Finally, driven by these clinical demands, future developments in clinical flow cytometry are suggested.

Clinical demandClinical flow cytometryQuantitative flow cytometrySpectral flow cytometryImaging flow cytometry

Ting Zhang、Mengge Gao、Xiao Chen、Chiyuan Gao、Shilun Feng、Deyong Chen、Junbo Wang、Xiaosu Zhao、Jian Chen

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State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,People's Republic of China

School of Future Technology,University of Chinese Academy of Sciences,Beijing 100049,People's Republic of China

Peking University People's Hospital,Peking University Institute of Hematology,National Clinical Research Center for Hematologic Disease,Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation,Beijing 100044,People's Republic of China

State Key Laboratory of Transducer Technology,Shanghai Institute of Microsystem and Information Technology,Chinese Academy of Sciences,Shanghai 200050,People's Republic of China

School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,People's Republic of China

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国家自然科学基金国家自然科学基金国家自然科学基金中国科学院项目中国科学院项目国家重点研发计划

619220796182510762121003GJJSTD20210004Y2019272021YFC2500300

2022

10.1063/10.0015301

纳米技术与精密工程(英文)
中国微米纳米技术学会,天津大学

纳米技术与精密工程(英文)

CSTPCDCSCDEI
影响因子：0.476
ISSN：1672-6030
年,卷(期)：2022.5(4)
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