首页|Superwettable interface towards biodetection in confined space

Superwettable interface towards biodetection in confined space

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The detection of biomarkers with both high sensitivity and specificity is crucial for the diagnosis and treatment of related diseases.However,many current detections employ ex-situ detection method and non-confined condition,thus have many problems,which may eventually lead to inaccurate detection results.Compared to detection in non-confined space,detection in confined space can better reflect the real in-vivo situation.Therefore,the construction of detection for target molecules in confined space has great significance for both theoretical research and practical application.To realize the detection of target molecules in confined space,the probes should accurately enter the confined space where the target molecules reside and interact with the interface.Thus,how to explore and utilize the properties of the interface(for example,bioinspired superwettability)has always been a hot and difficult topic in this field.Herein,the recent advances and our efforts in recent 10 years on detection of bio-target molecules in confined space with superwettable interface have been introduced from the perspective of the detection methods.The suitable and most widely employed detection methods for target molecules in confined spaces are introduced firstly.Then,recent progresses for related detections based on visual,optical,and electrochemical detection methods are presented successively.Finally,the perspective for detection in confined space is discussed for the future development of biochemical detection.

biodetectionsuperwettabilityconfined spaceinterface

Zexu Pang、Zhikang Cao、Wanlu Li、Wenxia Xu、Yingying Zhang、Qitao Zhou、Jing Pan、Fan Xia

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State Key Laboratory of Biogeology and Environmental Geology,Engineering Research Center of Nano-Geomaterials of the Ministry of Education,Faculty of Materials Science and Chemistry,China University of Geosciences,Wuhan 430074,China

National Natural Science Foundation of ChinaGuangDong Basic and Applied Basic Research FoundationNational Key R&D Program of ChinaNational Key R&D Program of ChinaJoint NSFC-ISF Research Grant Program

222041502021A15151100362021YFA12004032018YFE020690022161142020

2024

10.1007/s12274-023-6108-x

纳米研究(英文版)

纳米研究(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.17(2)
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