Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

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外文摘要：Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic surgeries.Although suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous adhesion.In this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon repairing.To address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(ⅰ)instant and tough adhesion to Achilles tendon tissues,(ⅱ)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(ⅲ)anti-postsurgical peritendinous adhesion.Combining our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon repairing.The hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

外文关键词：

hydrogelsphase separationbioadhesionrobustnesstendon repairing

作者：

Jun Zhang、Xingmei Chen、Jingseng Lin、Pei Zhang、Iek Man Lei、Yue Tao、Jiajun Zhang、Tian Luo、Ji Liu

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作者单位：

Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen 518055,China

Research and Innovation Center,SKG Health Technology,Shenzhen 518000,China

SAFE (Shenzhen) Medical Technology Company Limited,Shenzhen 518000,China

Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen 518055,China

Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities,Southern University of Science and Technology,Shenzhen 518055,China

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基金：

Natural Science Foundation of Guangdong ProvinceNatural Science Foundation of Guangdong ProvinceBasic Research Program of ShenzhenBasic Research Program of ShenzhenScientific Research Platforms and Projects of University of Guangdong Provincial Education OfficeScience,Technology,and Innovation Commission of Shenzhen Municipality

项目编号：

2022A15150101522021A1515110735JCYJ20210324105211032GJHZ202107051418090302022ZDZX3019ZDSYS20200811143601004

出版年：

2024

DOI：

10.1007/s12274-023-5918-1

纳米研究(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.17(2)

参考文献量43