Bioinspired metal-organic framework nanozyme reinforced with thermosensitive hydrogel for regulating inflammatory responses in Parkinson's disease

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外文摘要：Parkinson's disease(PD)is a prevalent neurodegenerative disorder accompanied by movement disorders and neuroinflammatory injury.Anti-inflammatory intervention to regulate oxidative stress in the brain is beneficial for managing PD.However,traditional natural antioxidants have failed to meet the clinical treatment demands due to insufficient activity and sustainability.Herein,Cu-doping zeolite imidazolate framework-8(ZIF-8)nanozyme is designed to simulate Cu/Zn superoxide dismutase(SOD)by biomimetic mineralization.The nanozyme composite is then integrated into thermosensitive hydrogel(poly(lactic-co-glycolic acid)-poly(ethylene glycol)-poly(lactic-co-glycolic acid)(PLGA-PEG-PLGA))to form an effective antioxidant system(Cu-ZIF@Hydrogel).The thermosensitive hydrogel incorporating nanozymes demonstrate distinct viscoelastic properties aimed at enhancing local nanozyme adhesion,prolonging nanozyme retention time,and modulating antioxidant activity,thus significantly improving the bioavailability of nanozymes.At the cellular and animal levels of PD,we find that Cu-ZIF@Hydrogel bypass the blood-brain barrier and efficiently accumulate in the nerve cells.Moreover,the Cu-ZIF@Hydrogel significantly alleviate the PD's behavioral and pathological symptoms by reducing the neuroinflammatory levels in the lesion site.Therefore,the hydrogel-incorporating nanozyme system holds great potential as a simple and reliable avenue for managing PD.

外文关键词：

bioinspired nanozymethermosensitive hydrogelParkinson's diseaseoxidative stressneuroinflammatory

作者：

Xiaowan Fan、Tao Zhang、Xin Ding、Yushuo Gu、Qing Li、Wei Jiang、Kelong Fan

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作者单位：

Nanozyme Medical Center,Academy of Medical Science,Zhengzhou University,Zhengzhou 450001,China

Application Center for Precision Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

Department of General Surgery,Strategic Support Force Medical Center,Beijing 100101,China

Department of Anesthesiology,Pain and Perioperative Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

Department,Central-China Branch of National Center for Cardiovascular Diseases,Hean Cardiovascular Disease Center,Fuwai Central-China Hospital,Central China Fuwai Hospital of Zhengzhou University,Zhengzhou 450046,China

CAS Engineering Laboratory for Nanozyme,Key Laboratory of Protein and Peptide Pharmaceuticals,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China

University of Chinese Academy of Sciences,Beijing 101408,China

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基金：

CAS Interdisciplinary Innovation Team

项目编号：

JCTD-2020-08

出版年：

2024

DOI：

10.1007/s12274-023-6304-8

纳米研究(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.17(2)

参考文献量24