首页|Mesenchymal stem cell-derived exosomes:Versatile nanomaterials for skin wound treatment

Mesenchymal stem cell-derived exosomes:Versatile nanomaterials for skin wound treatment

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Accumulating studies reveal that mesenchymal stem cells(MSCs)promote skin wound healing mainly through the paracrine effects.Exosomes,one of the crucial paracrine mediators in wound healing,are cell-derived nanosized membranous vesicles containing diverse bioactive cargoes.With the potent ability of modulating skin cell behaviors,MSC-derived exosomes(MSC-Exos)are regarded as a promising nanomaterial for regenerative wound therapy.Under hostile conditions,MSC-Exos are efficient in protecting skin cells from severe damage and restoring their function.According to recent studies,MSC-Exos possess remarkable pro-healing effects in a variety of skin wounds,typically resulting in increased wound closure,inhibited scar tissue formation,and better restoration of skin function.To further enhance the therapeutic potential of MSC-Exos,the development of applicable pretreatment strategies and the optimization of exosome delivery are under intensive investigation.Herein,we summarize current research progress of MSC-Exos for skin wound treatment,with an emphasis on the biological effects of these nanovesicles,the repair mechanisms,and future challenges in clinical translation.

exosomesmesenchymal stem cellsdiabetic woundsburn woundsscarwound healing

Yuzhen Xiao、Hexi Li、Junhui Zhang、Songyun Yang、Chunsen Zhang、Yizhou Huang、Xin Tang、Huiqi Xie

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Department of Orthopedic Surgery and Orthopedic Research Institute,Laboratory of Stem Cell and Tissue Engineering,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu 610041,China

West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China

Sports Medicine Center,West China Hospital,Sichuan University,Chengdu 610041,China

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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaPost-Doctor Research Project,West China Hospital,Sichuan University

32071331316007922018HXBH053

2024

10.1007/s12274-023-6080-5

纳米研究(英文版)

纳米研究(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.17(4)
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