Engineered plant extracellular vesicles for autoimmune diseases therapy

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外文摘要：Autoimmune diseases(AID)encompass a diverse array of conditions characterized by immune system dysregulation,resulting in aberrant responses of B cells and T cells against the body's own healthy tissues.Plant extracellular vesicles(PEVs)are nanoscale particles enclosed by phospholipid bilayers,secreted by plant cells,which facilitate intercellular communication by transporting various bioactive molecules.Due to their nanoscale structure,safety,abundant sources,low immunogenicity,high yield,biocompatibility,and effective targeting of the colon and liver,PEVs are regarded as a promising platform for the treatment of AID.This review provides a comprehensive summary of PEV biogenesis,physicochemical and biological properties,internalization mechanisms,isolation methods,and their applications in various diseases,with a specific focus on their potential roles in AID.Additionally,we propose engineering approaches and administration methods for PEVs.Finally,we present an overview of the advantages and challenges associated with utilizing PEVs for the treatment of AID.By gaining a comprehensive understanding of PEVs,we anticipate the development of innovative therapeutic strategies for AID.Natural and engineered PEVs hold substantial promise as a valuable resource for innovative technologies in AID treatment.

外文关键词：

autoimmune diseasesplant extracellular vesiclesextracellular vesiclesengineering modification

作者：

Ruina Han、Yan Wu、Yafei Han、Xiangfei Liu、Han Liu、Jiacan Su

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作者单位：

Institute of Translational Medicine,Shanghai University,Shanghai 200444,China

Organoid Research Center,Shanghai University,Shanghai 200444,China

National Center for Translational Medicine(Shanghai)SHU Branch,Shanghai University,Shanghai 200444,China

Department of Orthopedics,Shanghai Zhongye Hospital,Shanghai 200941,China

Department of Orthopedics,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaIntegrated Project of Major Research Plan of National Natural Science Foundation of ChinaShanghai Committee of Science and Technology Laboratory Animal Research Project

项目编号：

82230071822023449224930323141900600

出版年：

2024

DOI：

10.1007/s12274-023-6112-1

纳米研究(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.17(4)

参考文献量158