首页|Advances of nanoparticles in transmucosal drug delivery

Advances of nanoparticles in transmucosal drug delivery

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Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site.However,many challenges still remain in its clinical application,including low drug availability and limited retention time in the mucosa.The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong permeability.In this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed.

nanoparticles(NPs)transmucosal drug deliverymucosal barriersbiomaterials

Li Zhang、Changwei Yang、Yingxiang Song、Tao Sheng、Junyan Li、Jicheng Yu、Xiaohong Wu、Xiao Ye

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Geriatric Medicine Center,Department of Endocrinology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Hangzhou 310014,China

Key Laboratory for Diagnosis and Treatment of Endocrine Gland Diseases of Zhejiang Province,Hangzhou 310014,China

Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

Jinhua Institute of Zhejiang University,Jinhua 321299,China

Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 311121,China

Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China

National Key Laboratory of Advanced Drug Delivery and Release Systems,Zhejiang University,Hangzhou 310058,China

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National Natural Science Foundation of ChinaZhejiang Provincial Natural Science FoundationZhejiang Provincial Natural Science FoundationNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaJoint Funds of the Zhejiang Provincial Natural Science Foundation of ChinaScience and technology innovation leading talent project of Zhejiang ten thousand people planZhejiang province health innovative talents project

82100911LQ18H070004LY19H0700023227138081970714LHDMZ23H0700012021R520222021-CXRC07-01

2024

10.1007/s12274-023-6188-7

纳米研究(英文版)

纳米研究(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.17(4)
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