首页|A novel structure of ultra-high-loading small molecules-encapsulated ZIF-8 colloid particles

A novel structure of ultra-high-loading small molecules-encapsulated ZIF-8 colloid particles

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The safety of nanoparticle-based drug delivery systems(DDSs)for cancer treatment is still a challenge,restricted by the intrinsic cytotoxicity of drug carriers and leakage of loaded drug.Here,we propose a novel nanocarrier's cytotoxicity avoidance strategy by synthesizing an encapsulation core-shell structure of zeolitic imidazolate framework-8(ZIF-8)-based colloid particles(CPs)with an amorphous ZIF-8 skin.This encapsulation structure achieves an ultra-high loading rate(LR)of 90％(i.e.,9 mg doxorubicin(DOX)per 1 mg ZIF-8)for DOX and the protection of DOX from leaking.Notably,to deliver unit-dose drug,this ultra-high LR of 90％significantly reduces the usage of ZIF-8 to 1.2％(2 orders of magnitude)compared to that of DOX@ZIF-8 with a 10％LR,in which cytotoxicity of ZIF-8 could well below the safety limit and then be relatively ignored.Safety,drug delivery efficacy,scale-up ability,and universality of this encapsulation structure have been further verified.Our findings suggest the great potential of this ZIF-8-based encapsulation core-shell structure in the field of drug delivery.

metal-organic frameworkszeolitic imidazolate framework-8(ZIF-8)drug deliverynanoparticlesnanostructures

Pengfei Duan、Yunhe An、Xiaoxiao Wei、Yanjie Tian、Di Guan、Xiangwen Liu、Lanqun Mao

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Institute of Analysis and Testing,Beijing Academy of Science and Technology(Beijing Center for Physical and Chemical Analysis),Beijing 100089,China

College of Chemistry,Beijing Normal University,Beijing 100875,China

National Natural Science Foundation of ChinaBeijing Natural Science FoundationBeijing Municipal Financial Project BJAST Scholar Programs BBeijing Municipal Financial Project BJAST Young Scholar Programs BBeijing Municipal Financial Project BJAST Budding Talent Program

221010292222006BS202001YS20220223CE-BGS-01

2024

10.1007/s12274-023-6172-2

纳米研究(英文版)

纳米研究(英文版)

CSTPCD
ISSN：
年,卷(期)：2024.17(4)
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