Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy

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外文摘要：Enhancing the therapeutic effect of existing treatments or developing new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant tumors.Photodynamic therapy(PDT)is an emerging treatment modality,and the key for achieving high-efficiency PDT is to select light with strong tissue penetration depth and enhance the generation of reactive oxygen species(ROS).Although the upconversion nanoparticles(UCNPs)modified with the photosensitizers could achieve PDT with strong penetration depth under near-infrared light irradiation,the ROS generated by traditional single-pathway PDT is still insufficient.Herein,we developed a novel nanoconjugate(UCNP-Ce6/AIEgen)for dual-pathway reinforced PDT,in which the UCNPs were co-modified with chlorin e6(Ce6)and luminogen with aggregation-induced emission(AIEgen).Due to the presence of AIEgen,UCNP-Ce6/AIEgen could avoid aggregation-caused luminescence quenching in biological water environments and convert upconversion luminescence(UCL)of UCNPs to Ce6-activatable fluorescence.Therefore,under the irradiation of 808 nm laser,UCNP-Ce6/AIEgen can not only undergo direct lanthanide-triplet energy transfer to activate Ce6,but also convert the UCL of UCNPs to the light that can activate Ce6 through Förster resonance energy transfer to generate more ROS,thus promoting tumor cell apoptosis.This work broadens the applications of nanoconjugates of lanthanide-based inorganic materials and organic dyes,and provides a conception for reinforced PDT of tumors.

外文关键词：

upconversion nanoparticleaggregation-induced emissiondirect lanthanide-triplet energy transferFörster resonance energy transferphotodynamic therapy

作者：

Ruohao Zhang、Yu Lu、Yifei Zhou、Kehong Lv、Xinyu Fu、Jitong Gong、Shuang Yao、Xiaozhen Wang、Jing Feng、Hongjie Zhang

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作者单位：

State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China

School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China

College of Chemistry,Jilin University,Changchun 130012,China

Department of Breast Surgery,General Surgery Center,the First Hospital of Jilin University,Changchun 130021,China

Department of Chemistry,Tsinghua University,Beijing 100084,China

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基金：

Ministry of Science and Technology of ChinaMinistry of Science and Technology of ChinaNational Natural Science Foundation of ChinaInternational Partnership Program of Chinese Academy of SciencesDepartment of Science and Technology of Jilin ProvinceDepartment of Science and Technology of Jilin ProvinceYouth Innovation Promotion Association of Chinese Academy of Sciences

项目编号：

2021YFF07018002022YFB350370022020102003121522KYSB2019002220220101063JC20200201423JCY201947

出版年：

2024

DOI：

10.1007/s12274-023-6202-0

纳米研究(英文版)

CSTPCD

ISSN：

年,卷(期)：2024.17(4)

参考文献量44