Aiming at the problems of low space use efficiency,insufficient space fitness and high noise impact score of the existing op-timal design methods of building interior space,this paper proposes a research on the optimal design of building interior space based on BIM digital mode.Applying Revit software to construct BIM model,based on BIM digital modal information,extract the topological relation--spatial topological connection diagram of architectural interior space,determine the optimization design objectives of architectural inte-rior space,apply derivative design method--the core is to improve genetic algorithm,and obtain the best optimal design scheme of ar-chitectural interior space through continuous iterative operation.The research objective can be realized by implementing the optimal de-sign scheme.The experimental results show that after the proposed method is applied,the efficiency of indoor space use is 90%,the max-imum spatial fitness is 0.95,and the minimum noise impact score is 0.09.