江苏工程职业技术学院学报2024,Vol.24Issue(1) :1-7.DOI:10.19315/j.issn.2096-0425.2024.01.001

水飞蓟宾治疗乳腺癌研究进展

Research Progress on the Treatment of Breast Cancer with Silybin

姚文瑾 冯成亮 张荣荣 朱志杰
江苏工程职业技术学院学报2024,Vol.24Issue(1) :1-7.DOI:10.19315/j.issn.2096-0425.2024.01.001

水飞蓟宾治疗乳腺癌研究进展

Research Progress on the Treatment of Breast Cancer with Silybin

姚文瑾 1冯成亮 1张荣荣 2朱志杰1
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作者信息

  • 1. 江苏工程职业技术学院纺织服装学院,南通 226006
  • 2. 江苏权正检验检测有限公司,南通 226000
  • 折叠

摘要

乳腺癌发病率高,严重威胁女性健康,寻找治疗乳腺癌的药物至关重要.为给水飞蓟宾在乳腺癌临床治疗中的进一步应用提供理论基础,研究综述了水飞蓟宾在乳腺癌细胞中的作用机制:水飞蓟宾能阻滞乳腺癌细胞周期;能通过线粒体途径有效抑制乳腺癌细胞的侵袭和迁移,诱导癌细胞的自噬和凋亡;能多途径调节肿瘤微环境,抑制肿瘤血管生成,抑制乳腺癌细胞的增殖并诱导凋亡;具有强大的抗转移活性,可与其他天然药物联用发挥协同抗癌作用.

Abstract

Breast cancer poses a serious threat to women's health owing to its high incidence,and thus finding drugs for its treatment is crucial.In order to provide a theoretical basis for further clinical application of silybin to the treatment of breast cancer,the study reviewed the mechanism of silybin on breast cancer cells.It shows that silybin can block the cycle of breast cancer cells and induce their autophagy and apoptosis so that the invasion and migration of such cells can be effectively inhibited through the mitochondria,and that it can regulate the tumor microenvironment in multiple ways to inhibit the tumor angiogenesis and prevent the cancer cells from proliferating and induce their apoptosis.In addition,it has strong activity of anti-metastasis,which can be used together with other natural medicine to exert synergistic effects on cancer.

关键词

水飞蓟宾/乳腺癌/抗转移/抗肿瘤

Key words

silybin/breast cancer/anti-metastasis/antitumor

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基金项目

南通市基础科学研究计划青年科技人才创新专项(JCZ2022101)

江苏省高校自然科学基金面上项目(22KJB540002)

中国博士后科学基金(2021M691676)

出版年

2024
江苏工程职业技术学院学报
南通纺织职业技术学院

江苏工程职业技术学院学报

影响因子:0.264
ISSN:1671-6191
参考文献量71
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