The synthesis of triazole compounds via visible light-mediated organic photosensitizer catalysis
Photoinduced reactions,combined with organometallic catalysis,small molecule catalysis,and asymmetric catalysis,have achieved many structurally complex heterocyclic compounds and natural organic compounds,enriching,and developing the research content of organic reaction methodology.Among numerous heterocyclic compounds,tria-zole is an important class of five membered heterocyclic compounds with biological and pharmacological activities,widely used in pharmaceuticals,pesticides,and other fine chemical fields.Based on this,this study synthesized a series of 1,4,5-substituted 1,2,3-triazole compounds by[3+2]cycloaddition under visible light mediation,using azide and benzoylacetonitrile as raw materials and pyrene as organic photocatalysts,and the corresponding target compounds were characterized using data such as nuclear magnetic resonance H-spectroscopy,C-spectroscopy,high-resolution mass spectrometry and melting point.The experimental results show that the reaction conditions are mild,the regiose-lectivity is high and the functional group compatibility is good.In addition,the reaction operation is simple,the yield is as high as 99％,and the reaction mechanism reveals the potential reaction course of this photoconversion.This study provides a simple,efficient,and green method for the synthesis of 1,2,3-triazole derivatives,simultaneously enriching the molecular library of triazole heterocyclic compounds.
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