Advances in the Synthesis and Application of Spiro[4.4]-nonane-1,6-dione
Motivated by the development of chiral ligands and catalysts,asymmetric catalytic reactions have been extensively known as one of the most efficient ways to obtain optically pure compounds.Consequently,the exploration of privileged skeletons and the development of corresponding chiral ligands and catalysts have become pivotal objectives in asymmetric catalysis research.Since the 1990s,chiral spiro-scaffolds have played a significant role in the design and synthesis of effective chiral ligands and catalysts.Among these,spiro[4.4]-nonane-1,6-dione stands out as a representative chiral spiro core structure and has been applied in the design,synthesis,and application of chiral auxiliaries,ligands,and catalysts.This paper provides a comprehensive review of the research history regarding the synthesis and applications of spiro[4.4]-nonane-1,6-dione.
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