Tumor Metabolism Reprogramming Provides Novel Targets for Glioblastoma Therapy
Glioma research has witnessed significant progress in recent decades,yet effective treatments for glio-blastoma remain elusive,leading to dismal prognoses for patients.Metabolic reprogramming stands out as a cru-cial hallmark of gliomas.With advancements in metabolic technologies,novel mechanisms of intracellular meta-bolic dysregulation,influenced by glioma gene mutations and metabolic microenvironmental control,are unveiled.These encompass alterations in glucose,lipid,and amino acid metabolism.Targeting metabolic path-ways regulated by genetic mutations has emerged as a promising avenue for selectively eradicating glioma cells.Several potential therapeutic agents are currently under investigation,demonstrating remarkable efficacy in in vivo models.This review provides a comprehensive overview of recent advances in understanding the mecha-nisms of metabolic abnormalities in gliomas and the advancements in targeted drug therapies for this challenging disease.
国家科技期刊平台
NSTL
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