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黑骨藤对PC12细胞氧化损伤的保护研究

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[目的]研究黑骨藤提取物对H2O2诱导的PC12氧化损伤的保护作用。[方法]使用H2O2氧化压力诱导PC12出现氧化损伤,检测黑骨藤乙醇提取物对PC12细胞的保护作用。[结果]与模型对照组相比,黑骨藤乙醇提取物浓度在16~128μg/mL时,能显著提高PC12细胞的存活率,呈典型的量效关系。[结论]黑骨藤乙醇提取物具有抗氧化损伤作用。
Protective Effects of Periploca forrestii Schltr. Root Extract Against Cytotoxicity Induced by Hydrogen Peroxide in PC12 Cells
[Objective] The aim was to study the protective effects of Periploca forrestii Schltr.root extract against cytotoxicity induced by hydrogen peroxide in PC12 cells.[Method] The model of PC12 cells toxicity induced by hydrogen peroxide was established and the protective effects of Periploca forrestii Schltr.root extract on PC12 cells were detected.[Result] Compared to negative control,Periploca forrestii Schltr.root extract could protect PC12 cells at concentration ranges of 16-128 ug/mL at a dose-response manner.[Conclusion] Periploca forrestii Schltr.root extract showed anti-oxidative effect on PC12 cells.

Periploca forrestii Schltr.PC12 cellsAnti-oxidative effect

张贵源、龚莉莉、余跃生、王恒、陆玉炯、杨再昌

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黔南民族医学高等专科学校,贵州都匀558000

贵州大学,贵州贵阳550003

黑骨藤 PC12细胞 抗氧化

贵州省教育厅自然科学类一般项目

2010

2012

宁夏农林科技
宁夏农林科学院

宁夏农林科技

影响因子：0.27
ISSN：1002-204X
年,卷(期)：2012.53(8)
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