Monocyclic β-lactam antibiotics are an important hotspot in the research and development of new antibiotics,and the introduction of methyl at C5 position of aminothiazole is an important solution.In this paper,based on the original synthesis route,through in-depth analysis of the reaction mechanism,the methylated aminothiazole side chain acid at C5 was efficiently synthesized from 3-oxoethylpentanoate as the starting material through five steps of reaction in high efficient way,which laid the foundation of the preclinical research for the candidate drug target compound DPI-2016.
Monocyclic β-lactam antibioticsAmino thiazole side chain acidAztreonam
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NSTL
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