Study on the Relationship between Pre-pregnancy Body Mass Index and Serum Lipid and Thyroid Hormone Levels during Pregnancy and Its Influence on the Incidence of Grestational Diabetes Mellitus
Objective To investigate the correlation between abnormal prepregnancy body mass index(BMI)and the levels of blood lipid and thyroid hormone during pregnancy and its influence on the incidence of gesta-tional diabetes mellitus.Methods A total of 107 patients with gestational diabetes mellitus(GDM)treated in our hospital from July 2021 to December 2022 were selected as GDM group.Another 100 healthy pregnant women in the same period were selected as healthy control group.Glucose and lipid metabolism indexes were detected,and the serum thyroid hormone level was monitored.Retrospective analysis was conducted on two groups of pre pregnancy body mass index(pBMI),blood lipid indicators,serum thyroid hormone levels,and the correlation between pBMI and blood lipid and thyroid hormone indicators.Multivariate Logistic regression was used to analyze the correlation between pBMI,blood lipid indicators,thyroid hormone indicators,and GDM.Re-sults Compared with healthy control group,pBMI in GDM group was higher,and the difference was statisti-cally significant(P<0.05).Compared with the healthy control group,pBMI<18.5 kg·m-2,18.5 kg·m-2≤pBMI≤23.9 kg·m-2 were lower in the GDM group,and pBMI>23.9 kg·m-2 was higher in the GDM group(P<0.05).Compared with the healthy control group,TG and LDL-C levels were increased in the GDM group,the HDL-C level was decreased(P all<0.05).Compared with the healthy control group,the lev-els of T3 and FT4 in GDM group were lower(P<0.05),and the levels of TSH were higher(P<0.05).There were no significant differences in T4 and FT3 levels between the two groups(P all>0.05).Pearson correlation analysis showed that pBMI was positively correlated with TG,LDL-C and TSH levels,but negatively correlated with HDL-C,T3 and FT4 levels(P all<0.05).Multivariate Logistic regression analysis showed that pBMI≥24.0 kg·m-2、TG≥1.7 mmol·L-1、LDL-C≥1.55 mmol·L-1、TSH≥4.2 μIU·mL-1,HDL-C<1.9 mmol·L-1、T3<1.3 nmol·L-1、FT4<12 pmol·L-1 were all risk factors for GDM(Pall<0.05).Conclusion pBMI elevation is closely related to lipid and thyroid hormone indexes,and play a crucial role in the occurrence and development of GDM.Dynamic monitoring of lipid and thyroid hormone levels is worthy of clinical attention.
pregnancy body mass indexblood fatthyroid hormonegestational diabetes mellitus
万方数据
维普
