Expression and Significance of Bcl-3,cyclin D1,P53,Ki-67 Proteins in Proliferative Lesions in Breast Ducts
Objective To investigate the expression and application value of Bcl-3,CyclinD1,P53 and Ki-67 in breast intraductal proliferative lesions.Methods Immunohistochemistry was used to detect the expression of Bcl-3,cyclin D1,P53 and Ki-67 proteins in the tissue of usual ductal hyperplasia(UDH),columnar cell lesion(CCL),atypical ductal hyperplasia(ADH)and ductal carcinoma in situ(DCIS).Results The expression of Bcl-3,cyclin D1,P53 and Ki-67 in UDH were slight.They were significantly expressed in CCL,ADH and DCIS,and the positive rate of the three groups increased gradually(P<0.05).The positive staining(++～+++)of Bcl-3,cyclin D1,P53 and Ki-67 in CCL,ADH and DCIS was statistically significant(P<0.05).Conclusion The expression of Bcl-3,cyclin D1,P53 and Ki-67 has high application value in the pathological diagnosis,differential diagnosis and clinical treatment of intraductal hyperplasia of breast,and can significantly improve the diagnostic accuracy of intraductal hyperplasia of breast.
Bcl-3cyclin D1P53proliferating nuclear proteinintraductal hyperplasia of breastimmunohis-tochemistry
万方数据
维普
