Objective This study aimed to explore the association of energy-adjusted DII(E-DII)with inflammatory factors and dyslipidemia.Methods Data came from Ningxia natural population cohort.According to the matched case-control design,245 subjects with dyslipidemia and 247 control subjects were included.Dietary surveys used the food frequency method and the E-DII was calculated.Spearman correlation analysis and binary Logistic regression models were used to analyze the relationship between E-DII and inflammatory factors and dyslipidemia,respectively.Results The mean values of blood lipid indicators(TC,TG,LDL-C)and inflammatory factors(IL-2,IL-6,TNF-α)in the case group were higher than those in the control group,while IL-18 was lower in the case group(Pall<0.05).The range of E-DII was from-2.86 to 3.81,and the mean value between the two groups showed no significant difference(P>0.05).When E-DII was divided into three quartiles,there was a positive correlation between IL-6 and E-DII in the neutral group(r=0.162,P=0.038),and a negative correlation between E-DII and IL-18 in the pro-inflammatory tendency group(r=-0.188,P= 0.016).In the Logistic regression model,after adjusting for confounding factors and in subgroup analyses of diabetic and non-diabetic populations,no association was found between E-DII and dyslipidemia,which was tested by trend analysis(Pall>0.05).Conclusion E-DII is related to IL-6 and IL-18,but not to dyslipidemia.
关键词
能量调整的膳食炎症指数/血脂异常/炎症标志物/病例对照研究
Key words
energy-adjusted dietary inflammatory index/dyslipidemia/inflammatory markers/case-control study
维普
万方数据