Research Progress of Animal Models Related to Sudden Unexpected Death in Epilepsy
This manuscript predominantly explores the advancements in animal model research pertinent to sud-den unexpected death in epilepsy(SUDEP).It highlights that generalized tonic-clonic seizures(GTCS)are not only a significant harbinger but also a principal risk factor in the manifestation of SUDEP.The etiology of SUDEP is multifaceted,encompassing cardiogenic,respiratory,and neurogenic elements,suggesting a synergis-tic interplay of various pathophysiological mechanisms.This review categorizes the animal models employed in SUDEP research into three distinct types:transgenic mouse models,audiogenic SUDEP models,and maximal electroshock seizure(MES)models.The development of innovative animal models and the augmentation of clin-ical research is imperative.These endeavors are pivotal for enhancing the prognostic outcomes and life quality of individuals afflicted with epilepsy and are instrumental in devising prospective strategies for the prevention and management of SUDEP.
sudden unexpected death in epilepsyrisk factorspathogenesisanimal models
万方数据
维普
