This manuscript predominantly explores the advancements in animal model research pertinent to sud-den unexpected death in epilepsy(SUDEP).It highlights that generalized tonic-clonic seizures(GTCS)are not only a significant harbinger but also a principal risk factor in the manifestation of SUDEP.The etiology of SUDEP is multifaceted,encompassing cardiogenic,respiratory,and neurogenic elements,suggesting a synergis-tic interplay of various pathophysiological mechanisms.This review categorizes the animal models employed in SUDEP research into three distinct types:transgenic mouse models,audiogenic SUDEP models,and maximal electroshock seizure(MES)models.The development of innovative animal models and the augmentation of clin-ical research is imperative.These endeavors are pivotal for enhancing the prognostic outcomes and life quality of individuals afflicted with epilepsy and are instrumental in devising prospective strategies for the prevention and management of SUDEP.
关键词
癫痫猝死/危险因素/发病机制/动物模型
Key words
sudden unexpected death in epilepsy/risk factors/pathogenesis/animal models
维普
万方数据