Research Progress on Mechanism of the Combination of Salvia Miltiorrhiza and Safflower Against Cerebral Ischemia-reperfusion Injury
Cerebral ischemia reperfusion injury(CIRI)refers to the inability to restore blood supply after a cer-tain period of cerebral ischemia,leading to more severe brain dysfunction.CIRI is a common feature and patho-physiological mechanism of ischemic stroke,which mainly causes neuronal damage through pathways such as increased excitatory amino acid toxicity in brain neurons,oxygen free radical damage,calcium overload,inflam-matory response,and cell apoptosis.The latest research suggests that CIRI's prevention and treatment metholo-gy is intravenous thrombolysis.However,CIRI is characterized by short treatment time windows and unfavorable prognosis due to the limitation.The combination of traditional Chinese medicine salvia miltiorrhizo and safflower has the effect of anti-CIRI,and good clinical efficacy.Its mechanism may be revalent to promote angiogenesis,anti-apoptosis and other effects.Taking vascular homeostasis as the starting key point,the paper discusses the biological mechanism of the combination of traditional Chinese medicine salvia miltiorrhizo and safflower in treating CIRI,providing a certain theoretical basis for subsequent related experiments and clinical studies.
salvia miltiorrhizosafflowercombinationcerebral ischemia reperfusion injurymechanismvascu-lar homeostasis
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