Functional Exploration of Core Methylation Driver Genes in Pancreatic Cancer
Objective To screen core methylation driver genes in pancreatic cancer,and to explore their bio-logical functions and clinical significance.Methods Based on the mRNA-seq data of pancreatic cancer in TCGA/GEO database and the matched clinical data,using R analysis software related data packages and some online analysis tools,we analyzed and obtained the methylated driver genes in pancreatic cancer,and further screened the core methylated driver proteins by using Lasso-Cox regression analysis,and investigated their functional characteristics and clinical significance in pancreatic cancer.Finally,a prognostic model was con-structed based on the core methylation driver genes and related investigations were carried out.Results Methylated driver genes ZSCAN18,FERMT1,LIPH,LAMA3 and S100A16 showed good diagnostic efficacy in pancreatic cancer,and the up-regulation of FERMT1,LIPH,LAMA3 and S100A16 was significantly correlated with poor prognosis of patients(P＜0.05).Whereas the up-regulation of ZSCAN18 was correlated with better prognosis of patient survival(P＜0.05).The prognostic model based on the methylation driver genes ZSCAN18,FERMT1,LIPH,LAMA3 and S100A 16 showed good predictive efficacy and had good potential for clinical ap-plication.Conclusion Methylation driver genes ZSCAN18,FERMT1,LIPH,LA MA 3 and S100A16 were po-tential diagnostic targets and prognostic markers for pancreatic cancer,and prognostic models based on these genes showed good predictive efficacy.
万方数据
维普
