Causal Relationship Between Gut Microbiota and Autism Spectrum Disorder:A Two-sample Mendelian Randomization Study
Objective Investigate possible causal associations between gut microbiota(GM)and autism spectrum disorder(ASD)using two-sample Mendelian randomization(MR).Methods The GM data is sourced from the meta-analysis of genome-wide association studies conducted by the MiBioGen alliance,involving 18 340 subjects,and the ASD meta-analysis is sourced from data released by the Integrated Epidemiology Unit Open Genome-wide Association Study(IEU Open GWAS)project,inverse variance weighted(IVW),weighted mode and weighted median estimator(WME)methods for two-sample MR were used.Cochran's Q test,MR-PRESSO,and MR-Egger intercept test were performed as sensitivity analyses to assess the robustness of the results.Results The results indicate that the Dorea(OR=0.783,95％CI:0.676-0.908),RuminococcaceaeUCG005(OR=0.781,95％CI:0.693-0.880),RuminococcaceaeUCG014(OR=0.863,95％CI:0.761-0.980),and Victivallis(OR=0.917,95％CI:0.857-0.981),may have a protective effect on ASD,while the genera Barnesiella(OR=1.182,95％CI:1.047-1.334),Parabacteroides(OR=1.213,95％CI:1.017-1.447),and Turicibacter(OR=1.129,95％CI:1.007-1.267)may increase the risk of ASD(Pall＜0.05).Conclusion There is a causal relationship between GM and ASD,and improving GM may have clinical benefits in preventing and treating ASD.
gut microhiotaautism spectrum disordermendelian randomization
万方数据
维普
