The Relationship between High-risk HPV Infection and Clinical Characteristics and Protein Expression in Breast Cancer
Objective To explore the correlation between high-risk human papilloma virus infection and clinical characteristics of breast cancer patients and the protein expression of nuclear factor-κB(NF-κB),p53,Ki-67 and human epidermal growth factor receptor 2(HER-2)in cancer tissues.Methods 124 patients with breast cancer who were treated in Zhangjiakou First Hospital of Hebei Province from January 2021 to February 2023 were selected.HPV infection was detected by flow cytometry fluorescence hybridization and the expression of NF-κB,p53,Ki-67 and HER-2 proteins was detected by immunohistochemical staining.HPV infection in patients with different clinical characteristics and the relationship between HPV infection and the expression of NF-κB,p53,Ki-67 and HER-2 proteins was analyzed.Results The infection rate of high-risk HPV was 70.97%.The infection rate of high-risk HPV in poorly differentiated patients was 88.46%,which was higher than that in patients with moderate to high differentiation(P＜0.05).The high-risk HPV infection rate in patients with lymph node metastasis was 89.74%,which was higher than in patients without lymph node metastasis(P＜0.05).The positive expression rates of NF-κB,p53,Ki-67 and HER-2 proteins in breast cancer patients with high-risk HPV infection were 72.73%,69.32%,87.50%and 39.77%,respectively,which was higher than those in breast cancer patients without high-risk HPV infection(P＜0.05).High risk HPV infection was positively correlated with the positive expression of NF-κB,p53,Ki-67 and HER-2 proteins(P all＜0.001).Conclusion High-risk HPV infection is associated with pathological features of breast cancer.Therefore,clinical attention should be paid to the adverse prognosis of breast cancer patients caused by high-risk HPV infection.
high-risk human papilloma-virusbreast cancernuclear factor-κBp53Ki-67human epidermal growth factor receptor-2
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