Childhood-onset systemic lupus erythematosus(cSLE)refers to an autoimmune disease that appears before the age of 18 and is characterized by multi-system and multi-organ damage,accounting for about 15%to 20%of the total number of cases.Compared with adult-onset patients,pediatric patients have higher disease activity,more aggressive disease,more kidney,blood,and central nervous system involvement,more severe organ damage,and worse prognosis.In recent years,more and more studies have been conducted on the treatment of cSLE.With the application of therapeutic concepts and new immunosuppressants,especially biological agents,the prognosis of cSLE has been improved.This article reviews the progress in the treatment of cSLE to provide some theoretical help for the treatment of clinical cSLE children.
维普
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