摘要
目的 分析银川市体检人群代谢相关脂肪性肝病(MAFLD)现状、临床特征及危险因素,为深入开展防控工作提供参考依据.方法 以2020年1月1日至12月31日在宁夏医科大学总医院健康体检的银川市常住居民为研究对象,分析其一般资料、实验室指标等检测结果.结果 共纳入体检人员12865人,MAFLD患者 4 155例,患病率 32.30%;男性患者 3 122 例,患病率 41.60%;女性患者 1 033 例,患病率 19.27%;男性患病率高于女性(χ2=436.104,P＜0.01).＞60 岁人群中,女性患病率(40.97%)高于男性(31.47%)(P＜0.01).MAFLD组的三酰甘油、总胆固醇、低密度脂蛋白、高密度脂蛋白、丙氨酸转氨酶、尿酸水平与非MAFLD组比较,差异均有统计学意义(P均＜0.05).多因素 Logistic回归分析显示,男性、天冬氨酸转移酶及肌酐是MAFLD的独立危险因素(P均＜0.05).结论 银川市体检人群MAFLD患病率较高,且男性和肥胖者居多.男性、天冬氨酸转移酶、肌酐是MAFLD的影响因素.
Abstract
Objective To investigate the current situation of metabolic associated fatty liver disease(MAFLD)in the physical examination population in Yinchuan,analyze its clinical characteristics and risk factors,and provide a reference basis for in-depth intervention,prevention,and control work.Methods The health checkups of permanent residents of Yinchuan City at the General Hospital of Ningxia Medical University from January 2020 to December were used as the study population,and the test results of general conditions and laboratory indicators were collected and statistically analyzed.Results A total of 12 865 physical examinations personnel were included,and 4 155 patients with MAFLD(32.30%),including 3 122 males(41.60%)and 1 033 females(19.27%),the prevalence of males was higher than that of females(χ2=436.104,P＜0.01).The prevalence rate of women(40.97%)was higher than that of men(31.47%),and the difference was statistically significant(P＜0.01).The differences in triglycerides,total cholesterol,low-density lipoprotein,high-density lipoprotein,alanine aminotransferase,and uric acid in the MAFLD group were significant compared to the non-MAFLD group(P all＜0.05).Multifactorial Logistic regression analysis showed that males,aspartate aminotransferase,and creatinine were independent risk factors for MAFLD,and the differences were statistically significant(P all＜0.05).Conclusion The prevalence of MAFLD is high in the Yinchuan city physical examination population,with a predominance of males and obese individuals,and males,aspartate aminotransferase,and creatinine are the influencing factors of MAFLD.
基金项目
国家重点专项课题项目(2018YFC1311504)
NETL
NSTL
万方数据