PI3K/AKT信号通路在卵巢癌中的作用机制研究进展
Research Progress on the Mechanism of PI3K/AKT Signaling Pathway in Ovarian Cancer
丛百红 1范妤 1宋亮 1史晓燕1
作者信息
摘要
近年来,卵巢癌在女性生殖系统疾病中越来越常见,并与多条信号转导通路异常相关.磷脂酰肌醇3-激酶(phosphatidylinositol 3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)信号通路可以直接或间接参与卵巢癌的病变过程,其与卵巢癌的发生、发展、侵袭、迁移、耐药性和血管生成等过程密切相关.本文对PI3K/AKT信号通路在卵巢癌中的研究进展进行综述,深入探索治疗卵巢癌的有效靶点,以期为卵巢癌的治疗提供理论依据.
Abstract
In recent years,ov arian cancer is becoming more and more common among female's reproductive system diseases,and is associated with multiple of abnormal signal transduction pathways.Phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway could directly or indirectly participate in the process of ovarian cancer,which is closely related to the development,invasion,migration,drug resistance and angiogenesis of ovarian cancer cells.This paper summarizes the research progress of PI3K/AKT signaling pathway's effects in ovarian cancer,in order to find the effective therapeutic targets of ovarian cancer and provide the theoretical basis for its treatment.
关键词
卵巢癌/PI3K/AKT信号通路/发生发展/侵袭/迁移/耐药性/血管生成Key words
ovarian cancer/PI3K/AKT signaling pathway/occurrence and development/invasion/migration/drug resistance/angiogenesis引用本文复制引用
基金项目
国家自然科学基金青年科学基金项目(81704073)
陕西省科技厅重点研发计划一般项目(2022SF-225)
陕西中医药大学胰、肝疾病的分子机制及中医药防治创新团队(2019-YL14)
陕西省科技厅项目(2021JM-472)
陕西省教育厅重点实验室项目(21JS014)
出版年
2024
NETL
NSTL
万方数据